Repurposed drug shows promise against endometriosis-related pain in animal model

Fenoprofen, a nonsteroidal anti-inflammatory drug, successfully alleviated pain and inflammation in a rodent model of endometriosis, according to a study funded by NICHD. The study team chose the drug after using a computer algorithm to evaluate nearly 1,300 existing compounds for their ability to reverse gene expression related to endometriosis disease.

NIH-funded report recommends strategies to advance inclusion of pregnant and lactating women in clinical research

A report issued by the National Academies of Sciences, Engineering, and Medicine makes recommendations to improve the safe and ethical inclusion of pregnant and lactating women in clinical research while reducing the risk of liability—the legal responsibility for causing harm. NICHD funded the committee to examine the real and perceived risks of liability arising from research conducted with these populations.

Hernia surgery safer after initial hospital discharge

It may be better for preterm infants to wait for hernia surgery until after they have been discharged from the newborn intensive care unit, suggests a study funded by NICHD. Infants who underwent surgery for inguinal hernia after discharge had fewer adverse events than those who had surgery while still in the hospital. The finding offers guidance on the safest timing of an essential procedure for a class of fragile infants.

Irregular sleep and late bedtimes associated with worse grades for high school students

Irregular sleep and late bedtimes are linked to worse grades and more school-related behavioral problems among teens, suggests a study funded by NICHD. The authors stated that interventions to promote regular sleep schedules may boost adolescents’ academic performance.

NIH-funded research leads to fluconazole labeling updates for use in infants

Research funded by NICHD’s Best Pharmaceuticals for Children Act program has led to infant use and dosing updates to the label of the antifungal drug fluconazole. Fluconazole, which is available in both oral and injectable form, is prescribed to prevent and treat various fungal infections, including candidiasis in infants.

Stress from peer exclusion may contribute to weight gain among children

Children experiencing higher social anxiety may be at greater risk for overeating and weight gain after being socially excluded by their peers, suggests a study from NICHD and other institutions. The researchers found that children who experienced a high stress level after completing an online task that simulates being ostracized and who also reported higher social anxiety were more likely to snack heavily after the simulation and gain weight over the next year and a half.

Stress, microRNA linked to uterine fibroids

Patients with uterine fibroids who scored high on stress questionnaires also had high levels of certain microRNAs in their uterine muscle tissue, suggests a preliminary study funded by NIH. Unlike RNA, which codes for proteins, microRNA regulates gene activity. The microRNAs the authors detected are known to be active in the formation of certain tumors. The findings add to previous studies linking stress to the development and severity of fibroids and suggest that the stress of structural racism and other issues may explain, at least in part, why African American women are more likely to develop fibroids than other groups.

Relatives of men with infertility may be at higher risk for certain cancers

A study funded by NICHD suggests that the relatives of men with no or a very low sperm count may be at higher risk for cancers of the bones, joints, colon, uterus, thyroid, and testes. The findings may lead to new insights into the environmental and genetic risk factors for certain cancers and to new ways of identifying people at risk for them.

Intramural division advances include zebrafish developmental atlas, bacterial virulence genes, and more

Developing a genetic atlas of embryonic zebrafish genes to aid in studies of early development, uncovering a link between maternal depression and accelerated placental aging, and identifying gene combinations leading to the virulence of disease-causing bacteria are among the recent advances of NICHD’s intramural researchers

Requests for Applications, Program Announcements

New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional) (PAR-24-161)

NICHD’s Data Sharing Resources


NICHD supports many resources and tools for researchers.

Featured This Month:

  • Datasets Catalog beta: Share Your Feedback

    The National Library of Medicine (NLM) recently launched an online tool that connects users to datasets from multiple repositories and improves data discoverability. NLM now invites feedback on the tool from the NICHD community on usability, use-cases, metadata, and other features. The Datasets Catalog beta adheres to FAIR (Findable, Accessible, Interoperable, and Reusable) data management principles and uses standardized, linked metadata to build a connected data model. User comments submitted through the “Give Feedback” function on the catalog webpage will inform future development, establish a community of users, gather analytics, and assess scalability and sustainability.


For information on other resources, visit NICHD’s Datasets & Research Resources.

NIH’s Office of Extramural Research News



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NICHD-Related Meetings, Conferences, and Events



For a full listing of previous and upcoming meetings and events, visit Scientific Meetings and Events.

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